Accession Number : ADA192659

Title :   Influence of Altitude and Caffeine during Rest and Exercise on Plasma Levels of Proenkephalin Peptide F.

Descriptive Note : Rept. for Jun-Jul 86,

Corporate Author : ARMY RESEARCH INST OF ENVIRONMENTAL MEDICINE NATICK MA

Personal Author(s) : Kraemer, William J ; Bock, Paul B ; Fulco, Charles S ; Gordon, Scott E ; Bonner, Jeff P

PDF Url : ADA192659

Report Date : Feb 1988

Pagination or Media Count : 18

Abstract : The purpose of this study was to examine the resting and exercise response patterns of plasma Peptide F immunoreactivity (ir) to altitude exposure (4300m) and caffeine ingestion (4mg.KgBW-1). Nine healthy male subjects performed exercise tests to exhaustion at sea level, during an acute altitude exposure (1 hr. hypobaric chamber) and after a chronic (17 day sojourn) altitude exposure. Using a randomized, double-blind/placebo experimental design, a placebo or caffeine drink was ingested 1 hour prior to exercise. Exercise (without caffeine) significantly (p0.05) increased plasma Peptide F ir values during exercise at chronic altitude only. Caffeine ingestion significantly increased plasma Peptide F ir concentrations during exercise an in the post-exercise period at sea level. Conversely, caffeine ingestion at altitude resulted in significant reductions in the post-exercise plasma Peptide F ir values. The results of this study demonstrate that the exercise and recovery response patterns of plasma Peptide F ir may be significantly altered by altitude exposure and caffeine ingestion. These data support further study examining relationships between Peptide F (and other ECPs) and epinephrine release in response to these types of physiological stresses. Keywords: Endogenous opioid peptides, Altitude acclimatization, Lactate, Cardiovascular, Caffeine, Endurance exercise.

Descriptors :   *ALTITUDE, *CAFFEINE, *EXERCISE(PHYSIOLOGY), ACCLIMATIZATION, BLOOD PLASMA, ENDURANCE(PHYSIOLOGY), EPINEPHRINE, HYPOBARIC CHAMBERS, INGESTION(ENGINES), LACTATES, LEVEL(QUANTITY), PATTERNS, PHYSIOLOGY, PLACEBOS, RECOVERY, RELEASE, RESPONSE, SEA LEVEL, STRESSES, CARDIOVASCULAR AGENTS, EXPOSURE(PHYSIOLOGY), STRESS(PHYSIOLOGY)

Subject Categories : Stress Physiology
      Pharmacology

Distribution Statement : APPROVED FOR PUBLIC RELEASE