Accession Number : ADA192696

Title :   Dermal Sensitization Potential of a Schistosome Topical Antipenetrant Lotion in Guinea Pigs.

Descriptive Note : Rept. for 15 Sep-2 Nov 87,

Corporate Author : LETTERMAN ARMY INST OF RESEARCH PRESIDIO OF SAN FRANCISCO CA

Personal Author(s) : Frost, Denzil F ; Magnuson, Dean K ; Korte, Don W , Jr

PDF Url : ADA192696

Report Date : Mar 1988

Pagination or Media Count : 38

Abstract : A schistosome topical antipenetrant lotion, containing 1% niclosamide, was tested for its potential to produce dermal sensitization. The Guinea Pig Maximization Test was used to evaluate dermal sensitization potential. Grade II (mild) dermal sensitization to the lotion was obtained in this study. These results suggest that there is probable risk that the schistosome topical antipenetrant lotion will induce contact sensitivity in humans.

Descriptors :   *SKIN(ANATOMY), *OINTMENTS, GUINEA PIGS, PROBABILITY, RISK, SCHISTOSOMA, SENSITIVITY, PENETRATION, PROTECTION, PREVENTIVE MEDICINE

Subject Categories : Pharmacology
      Anatomy and Physiology

Distribution Statement : APPROVED FOR PUBLIC RELEASE