Accession Number : ADA192826

Title :   Stress, Coping, and Infectious Illness: Persistently Low Natural Killer Cell Activity as a Host Risk Factor.

Descriptive Note : Annual rept. 1 Mar 87-29 Feb 88,

Corporate Author : PITTSBURGH UNIV PA

Personal Author(s) : Levy, Sandra M ; Herberman, Ronald B ; Whiteside, Theresa ; Simons, Anne

PDF Url : ADA192826

Report Date : 14 Mar 1988

Pagination or Media Count : 11

Abstract : Recent Japanese research, as well as pilot work preliminary to this current project, have pointed to a possible association between mood and lowered natural killer (NK) cell activity. In this previous work, a subgroup of individuals characterized by persistently low NK activity, and self-reported depression and fatigue, tended to report more serious illness on follow-up assessment. In this current study, we have accrued approximately, sixty-two normal individuals to this prospective project. Subjects are assessed both psychologically and physically at baseline, and are serially monitored over a six-month follow-up period in order to identify predictors of infectious illness over time. As in the preliminary work, we are finding that approximately 1/3 of the sample has persistently low NK activity, and this immunological pattern is strikingly associated with daily stress levels, as well as reports of depression and chronic anxiety. In a very preliminary fashion, we have also found a trend of association between this low NK activity pattern, and some categories of follow-up illness.

Descriptors :   *ILLNESS, *INFECTIOUS DISEASES, *STRESS(PSYCHOLOGY), *EMOTIONS, *FATIGUE(PHYSIOLOGY), ANXIETY, DAILY OCCURRENCE, IMMUNOLOGY, PATTERNS, PREDICTIONS, RATES, RISK, CELLS(BIOLOGY), CORRELATION

Subject Categories : Psychology
      Medicine and Medical Research

Distribution Statement : APPROVED FOR PUBLIC RELEASE