Accession Number : ADA192942

Title :   Interaction between Lung Mechanics and Gas Exchange by Low Volume High Frequency Pulmonary Ventilation in Patients with Respiratory Failure.

Descriptive Note : Final rept. 30 Sep 82-30 Sep 85,

Corporate Author : BRIGHAM AND WOMEN'S HOSPITAL BOSTON MA

Personal Author(s) : Drazen, Jeffrey M

PDF Url : ADA192942

Report Date : 30 Nov 1985

Pagination or Media Count : 20

Abstract : During the tenure of this contract, research was conducted both in patient volunteers and in hardware models. The patient studies led to the realization that dynamic hyperinflation of the lungs could commonly occur during high frequency ventilation and physiological experiments were conducted to determine the mechanisms responsible for this. The modelling studies (at MIT) first established the nature of the pressure-flow relationships which existed during high-frequency ventilation in a rigid tube model with lung-like geometry. The link between pressure and flow and gas transport was then established by measuring, in a similar model, the transport coefficients under circumstances dynamically similar to high frequency ventilation. Finally, since the patient studies suggested that expiratory flow limitation may be of critical value in understanding the dynamic hyperinflation observed in patient studies, fluid dynamic modelling of flow limitation was performed in order to better understand the physical factors influencing dynamic airway collapse. In this report, we shall summarize the work completed in each area, the details of which may be found in the appropriate annual reports.

Descriptors :   *BIOMECHANICS, *FAILURE, *GAS EXCHANGE(BIOLOGY), *RESPIRATORY SYSTEM, *MEDICAL RESEARCH, *RESPIRATION, *BIOMECHANICS, GASES, LUNG, PHYSIOLOGY, REPORTS, VENTILATION, THORAX, ANATOMICAL MODELS

Subject Categories : Medicine and Medical Research
      Anatomy and Physiology
      Biology

Distribution Statement : APPROVED FOR PUBLIC RELEASE