Accession Number : ADA192948

Title :   Synthesis and Screening of New Antimalarial Drugs.

Descriptive Note : Annual rept. 1 Jan-31 Dec 84,

Corporate Author : CENTRAL DRUG RESEARCH INST LUCKNOW (INDIA)

Personal Author(s) : Dhar, M M

PDF Url : ADA192948

Report Date : Apr 1985

Pagination or Media Count : 16

Abstract : The PL480 project has completed its second year and rhesus monkey models for radical curative and causal prophylactic testing have been validated. Construction of a large multistory primate colony building has been completed. The activities of 13 WRAIR and CDRI compounds were evaluated in the rhesus monkey model with five compounds found to be more active than the primaquine controls. Radical curative properties of 11 compounds (5 WRAIR and 6 CDRI) were evaluated with 5 compounds found to be more active than primaquine controls.

Descriptors :   *ANTIMALARIALS, CONTROL, DRUGS, MODELS, PRIMAQUINE, RHESUS MONKEYS, SYNTHESIS, TEST AND EVALUATION

Subject Categories : Pharmacology

Distribution Statement : APPROVED FOR PUBLIC RELEASE