Accession Number : ADA193115

Title :   Calculated Melting Temperature of Methylated Z-DNA.

Descriptive Note : Technical rept. Apr 81-Mar 88,

Corporate Author : PURDUE UNIV LAFAYETTE IND DEPT OF PHYSICS

Personal Author(s) : Hua, X. ; Feng, Y. ; Prohofsky, Earl W.

Report Date : 10 MAR 1988

Pagination or Media Count : 22

Abstract : There are two approaches to theoretical calculation of DNA melting temperature. One is based on a two states, quasi-one-dimensional lattice model in which the melting profile and differentiated melting curve could be calculated as a function of DNA length. Another way is the modified self-consistent effective phonon approximation (MSPA) in which the dynamic motional behavior of the DNA molecule during the melting process is detailed. We use the later approach to melting of methylated Z-DNA in this paper and compare our results to a similar calculation on unmethylated B-DNA. In this paper we present a calculation of melting temperature of methylated Z-DNA Deoxyribonucleic acid based on MSPA.

Descriptors :   *DEOXYRIBONUCLEIC ACIDS, *MELTING POINT, COMPUTATIONS, GRAPHS, LENGTH, MELTING, MOLECULES, PHONONS, MOLECULAR STRUCTURE, CRYSTAL LATTICES, METHYLATION, APPROXIMATION(MATHEMATICS), SYMMETRY(CRYSTALLOGRAPHY), HELIXES.

Subject Categories : Genetic Engineering and Molecular Biology
      Physical Chemistry
      Atomic and Molecular Physics and Spectroscopy
      Crystallography

Distribution Statement : APPROVED FOR PUBLIC RELEASE