Accession Number : ADA193339

Title :   Neurological Consequences of Acute and Chronic Cholinergic Blockage.

Descriptive Note : Annual rept. 1 Jun 85-31 May 86,

Corporate Author : MICHIGAN UNIV ANN ARBOR

Personal Author(s) : Domino, Edward F

PDF Url : ADA193339

Report Date : 02 Jun 1986

Pagination or Media Count : 60

Abstract : Various selective and nonselective M1 and M2 cholinergic antagonists have been studied for their presynaptic effects on 3H-acetylcholine release from the rat brain hippocampal slice preparation. Marked differences in potency and efficacy were observed that have direct implications with regard to the treatment of organophosphate poisoning. Keywords: Antidotes.

Descriptors :   *ANTIDOTES, *NERVE BLOCKING, *CHOLINESTERASE INHIBITORS, BRAIN, ORGANOPHOSPHATES, POISONING, RATS, SYNAPSE, CHOLINERGIC NERVES, HIPPOCAMPUS, PHARMACOLOGICAL ANTAGONISTS, ATROPINE

Subject Categories : Pharmacology

Distribution Statement : APPROVED FOR PUBLIC RELEASE