Accession Number : ADA194065

Title :   Low Doses of Atropine Sulfate Impair Retention of a Well-Learned Spatial Task.

Descriptive Note : Manuscript,

Corporate Author : ARMY RESEARCH INST OF ENVIRONMENTAL MEDICINE NATICK MA

Personal Author(s) : Bauch, T M ; Welch, D I ; Gallego, L

PDF Url : ADA194065

Report Date : Apr 1988

Pagination or Media Count : 21

Abstract : Retention of a well-learned spatial task was assessed in rats 10 minutes prior to, and 10, 20, 30, 40 and 50 minutes after treatment with 3, 10 or 30 mg/kg, iv, atropine sulfate or the equivalent volume of saline, iv. There was a variable dose effect for escape latency and choice accuracy measures of spatial retention. A relatively large dose of atropine sulfate (30 mg/kg, iv) significantly impaired choice accuracy and escape latency compared with the control group. Moreover, impairment in choice accuracy was observed with the control group. Moreover, impairment in choice accuracy was observed with smaller doses of atropine sulfate (3, 10 mg/kg, iv) than have previously been shown to disrupt spatial retention.

Descriptors :   *ATROPINE, *RETENTION(PSYCHOLOGY), *CHOLINESTERASE INHIBITORS, ACCURACY, CONTROL, DOSAGE, DOSE RATE, LOW RATE, SPATIAL DISTRIBUTION, SULFATES, VARIABLES, VOLUME, PHYSIOLOGICAL EFFECTS, RESPONSE(BIOLOGY), RATS, HIPPOCAMPUS

Subject Categories : Psychology
      Pharmacology

Distribution Statement : APPROVED FOR PUBLIC RELEASE