Accession Number : ADA194587

Title :   New Synthetic Approaches to TAT.

Descriptive Note : Interim rept. no. 6,

Corporate Author : BONN UNIV (GERMANY F R)

Personal Author(s) : Wamhoff, Heinrich

PDF Url : ADA194587

Report Date : 27 Aug 1987

Pagination or Media Count : 3

Abstract : In continuation and implementation of my recent travel & conference report dated July 24, 1987, we are still following up our three general synthetic strategies for developing new approaches to TAT: (a) ring synthetic methods from small molecules; (b) partially destructed hexamethylenetetramine (DAPT); (c) tetra- and hexamerization of methyleneimines in the presence of metal ions. A recent method (Dusemund & Schurreit, Arch. Pharm. (Weinheim) 319, 826 (1986)), to cyclize sulfonylurea in TFA to afford 1,5,2,4,6,8-dithiatetrazocine-1,1,5,5-tetroxide, proved to be not transferable to simple urea + TFA and only polymeric material has been formed; in a similar way, methylenediamine sulfate (nearly irreproducible) reacted with formaldehyde to give a complex mixture of decomposition products. The previously reported tetramerization of acetamide and formaldehyde gave only traces of TAT, detectable by TLC, but no isolation nor optimizing of the yield was possible.

Descriptors :   *SYNTHESIS(CHEMISTRY), *AMINES, ACETAMIDES, DECOMPOSITION, FORMALDEHYDE, HEXAMINES, IONS, ISOLATION, METALS, METHYLENES, MIXTURES, MOLECULES, POLYMERS, STRATEGY, UREA, IMINES, METHYL RADICALS, CYCLIC COMPOUNDS, SILANES

Subject Categories : Organic Chemistry

Distribution Statement : APPROVED FOR PUBLIC RELEASE