Accession Number : ADA194644

Title :   Development of Vaccines to Prevent Wound Infections Due to Anaerobic Bacteria.

Descriptive Note : Annual rept. 1 Oct 83-30 Sep 84,

Corporate Author : BRIGHAM AND WOMEN'S HOSPITAL BOSTON MA

Personal Author(s) : Kasper, Dennis L

PDF Url : ADA194644

Report Date : 01 Nov 1984

Pagination or Media Count : 12

Abstract : Progress on the two major objectives of this contract has been made. The first objective was to bottle and provide safety testing on a Bacteroides fragilis capsular polysaccharide preparation. The antigen was prepared in our laboratory and bottled by the Massachusetts State Public Health Laboratory. The material passed all safety and pyrogenicity studies required by the Food and Drug Administration. The second objective was to study the lymphokine produced by immunization with the polysaccharide. We have shown that a lysate of splenic T cells from animals immunized with the capsular polysaccharide, transfers protection to recipients. The protective material appears to be a lymphokine which is a protein, of small molecular weight. This factor is antigen specific for the immunizing antigen. Keywords: Human hybrido lymphokines; Anaerobic organisms; Laboratory animals.

Descriptors :   *ANAEROBIC BACTERIA, *VACCINES, *PREVENTIVE MEDICINE, ANAEROBIC PROCESSES, ANIMALS, ANTIGENS, DRUGS, IMMUNIZATION, INFECTIOUS DISEASES, LABORATORY ANIMALS, LYMPHOCYTES, MOLECULAR WEIGHT, POLYSACCHARIDES, PROTEINS, SAFETY, SPLEEN, TEST AND EVALUATION, WOUNDS AND INJURIES

Subject Categories : Pharmacology

Distribution Statement : APPROVED FOR PUBLIC RELEASE