Accession Number : ADA194707
Title : Chemical Preparation Laboratory for IND Candidate Compounds.
Descriptive Note : Annual rept. 17 Jan 87-16 Jan 88,
Corporate Author : PHARM-ECO LABS INC SIMI VALLEY CA
Personal Author(s) : Schubert, E M
PDF Url : ADA194707
Report Date : 05 Feb 1988
Pagination or Media Count : 84
Abstract : During the reporting period sixteen compounds were synthesized and submitted for testing. These compounds can be considered modified nucleosides derived from ribavirin,m arabinoadenosine and deazaguanosine, while the other half of the compounds are based on phenanthridone as the skeletal structure. Compounds which remain under investigation are selenazole, ribavirin metabolites, triazole carboxamides and prodrug ester. A large scale preparation of ribavirin amidine hydrochloride is presently in the preparatory stage. Keywords: Antivaral agents, Triazoles, Alkaloids, Phenanthridones.
Descriptors : *ALKALOIDS, *NUCLEOSIDES, CHEMICAL LABORATORIES, PREPARATION, SKELETON
Subject Categories : Organic Chemistry
Distribution Statement : APPROVED FOR PUBLIC RELEASE