Accession Number : ADA194707

Title :   Chemical Preparation Laboratory for IND Candidate Compounds.

Descriptive Note : Annual rept. 17 Jan 87-16 Jan 88,

Corporate Author : PHARM-ECO LABS INC SIMI VALLEY CA

Personal Author(s) : Schubert, E M

PDF Url : ADA194707

Report Date : 05 Feb 1988

Pagination or Media Count : 84

Abstract : During the reporting period sixteen compounds were synthesized and submitted for testing. These compounds can be considered modified nucleosides derived from ribavirin,m arabinoadenosine and deazaguanosine, while the other half of the compounds are based on phenanthridone as the skeletal structure. Compounds which remain under investigation are selenazole, ribavirin metabolites, triazole carboxamides and prodrug ester. A large scale preparation of ribavirin amidine hydrochloride is presently in the preparatory stage. Keywords: Antivaral agents, Triazoles, Alkaloids, Phenanthridones.

Descriptors :   *ALKALOIDS, *NUCLEOSIDES, CHEMICAL LABORATORIES, PREPARATION, SKELETON

Subject Categories : Organic Chemistry
      Pharmacology

Distribution Statement : APPROVED FOR PUBLIC RELEASE