Accession Number : ADA194783

Title :   An Evaluation of Two Configurations of Tricalcium Phosphate for Treating Craniotomies,

Corporate Author : ARMY INST OF DENTAL RESEARCH WASHINGTON DC

Personal Author(s) : Hollinger, Jeffrey O ; Schmitz, John P ; Mizgala, James W ; Hassler, Craig

PDF Url : ADA194783

Report Date : Jan 1986

Pagination or Media Count : 27

Abstract : Biodegradable beta-tricalcium phosphate disks (TCP) of 2 configurations were inserted into 15mm diameter craniotomy wounds and non-treated control sites were evaluated in 60 rabbits. There were no adverse tissue reactions and no apparent difference in the clinical appearance of the 12 and 24 week implanted disks. By 36 weeks and continuing to 48 weeks, the omnidirectional TCP (OTCP) implants were degrading more rapidly than the unidirectional TCP (UTCP) implants, with degradation progressing centripetally and replacement by woven bone and maturing lamellar bone. Host implant interface of both TCP configurations was a bone bond without interposed soft tissue. TCP disks may be clinically useful for craniotomy repair. Key words: Bone regeneration, tricalcium phosphate disks, calvaria; osteogenesis.

Descriptors :   *CALCIUM COMPOUNDS, *OSTEOGENESIS, *PHOSPHATES, *SURGICAL IMPLANTATION, BONDING, BONES, CONFIGURATIONS, DEGRADATION, DISKS, IMPLANTATION, INTERFACES, REGENERATION(PHYSIOLOGY), REPLACEMENT, SOFT TISSUES, WEAVING

Subject Categories : Medicine and Medical Research

Distribution Statement : APPROVED FOR PUBLIC RELEASE