Accession Number : ADA194945

Title :   Models of Cerebral-Body Perfusion and Cerebral Chemical Transport.

Descriptive Note : Annual rept. Oct 86-Oct 87,

Corporate Author : TECHNION - ISRAEL INST OF TECH HAIFA

Personal Author(s) : Sorek, S ; Bear, J ; Feinsod, M

PDF Url : ADA194945

Report Date : Mar 1988

Pagination or Media Count : 71

Abstract : In this research, a sequence of models is constructed to simulate the movement of fluids and chemicals in the cerebrovascular system. One model simulates the nonsteady response to perfusion in various sections of the brain. In a second model certain relevant part of the body are added to form a single brain-body model. A third model simulates the transport of selected chemical components through the cerebrovascular system. Predictions derived from the brain model were shown to be well within the range of available clinical observations. The brain-body model describes the interaction between the cerebral, the cardiovascular and the respiration systems. It is excited by expiration/inspiration fluxes and accounts for the effects of hydrostatic, environmental pressures, flight maneuvers with excessive (head to bottom) gravity acceleration and resuscitation procedures. In simulating chemical processes in the brain, the model accounts for carbon dioxide, bicarbonate, and hydrogen, as they are transport by perfusion and diffusion in the presence of chemical reactions. This model also focuses on the flow control between brain arteries and capillaries, due to changes in CO2 concentration.

Descriptors :   *CEREBROVASCULAR SYSTEM, *PERFUSION, *NEUROCHEMISTRY, ACCELERATION, ARTERIES, BOTTOM, BRAIN, CAPILLARIES(ANATOMY), CARBON DIOXIDE, CEREBRUM, CHEMICAL COMPOSITION, CHEMICAL PROPERTIES, CHEMICAL REACTIONS, CHEMICALS, CLINICAL MEDICINE, CONTROL, ENVIRONMENTS, FLIGHT MANEUVERS, GRAVITY, HYDROGEN, HYDROSTATIC PRESSURE, MODELS, RESPIRATION, RESUSCITATION, SEQUENCES, TRANSPORT, TRANSPORT PROPERTIES, BLOOD CIRCULATION, CARDIOVASCULAR SYSTEM, RESPIRATORY SYSTEM, INTERACTIONS, RESPONSE(BIOLOGY)

Subject Categories : Anatomy and Physiology
      Biochemistry

Distribution Statement : APPROVED FOR PUBLIC RELEASE