Accession Number : ADA195429

Title :   Development of Vaccines to Prevent Wound Infectious Due to Anaerobic Bacteria.

Descriptive Note : Final rept. 1 Jan 78-15 May 87,

Corporate Author : BRIGHAM AND WOMEN'S HOSPITAL BOSTON MA

Personal Author(s) : Kasper, Dennis L

PDF Url : ADA195429

Report Date : 26 Apr 1988

Pagination or Media Count : 9

Abstract : Progress on the two major objectives of this contract were made during this year. One lot of capsular polysaccharide of Bacteroides fragilis vaccine was tested for protective capacity in mice and found to function to induce a protective response. One human volunteer was immunized without adverse reactions occurring and the immunogenicity will be assessed. On the second specific aim, major progress was made in producing a specific T cell factor by cloning lymphocytes in vitro to produce the protective lymphokine. A small molecular weight antigen specific factor has been produced from hybridoma clones. This factor is of T cell origin and protects mice against experimental infection with Bacteroides fragilis. Keywords: Wounds; Infections.

Descriptors :   *INFECTIOUS DISEASES, *VACCINES, ADVERSE CONDITIONS, ANAEROBIC BACTERIA, BACTEROIDES, CAPSULES(PHARMACY), CLONES, GENETIC ENGINEERING, HUMANS, IN VITRO ANALYSIS, LYMPHOCYTES, MICE, POLYSACCHARIDES, PROTECTION, SENSITIZING, VOLUNTEERS, WOUNDS AND INJURIES, CELLS(BIOLOGY), IMMUNIZATION

Subject Categories : Pharmacology

Distribution Statement : APPROVED FOR PUBLIC RELEASE