Accession Number : ADA195557

Title :   Assessment of Neurological Effects of Drugs on Oculomotor and Visual Function in the Primate.

Descriptive Note : Annual rept. Sep 82-Aug 83,

Corporate Author : STATE UNIV OF NEW YORK UPSTATE MEDICAL CENTER SYRACUSE

Personal Author(s) : Keating, E G

PDF Url : ADA195557

Report Date : 15 Dec 1983

Pagination or Media Count : 45

Abstract : A number of cholinergic agents are deemed useful as prophylactics or antidotes to organophosphate poisoning yet have their own toxic effects. Dosages of these agents which are known to not grossly disrupt behavior may nonetheless degrade performance of sophisticated tasks required of the personnel of a modern mechanized army. The contract uses an animal model (primate) to assess the effects of cholinergic drugs on the performance of visual search and tracking tasks which mimic skills generally used in the field. The eye movements of cynomolgous monkeys (Macaca fascicularis) were recorded with the magnetic search coil technique while they searched for camouflaged targets or tracked moving targets. A preliminary analysis was completed of the effects of atropine on performance of the Visual Search and Target Tracking tests as well as on the effects on the Visual Search test of atropine/pralidoxime and pyridostigmine. (AW)

Descriptors :   *ANTIDOTES, *EYE MOVEMENTS, *PARASYMPATHOLYTIC AGENTS, *VISUAL PERCEPTION, ANIMALS, ARMY, ATROPINE, CAMOUFLAGE, COILS, DOSAGE, DRUGS, MACACA FASCICULARIS, MAGNETIC FIELDS, MECHANIZATION, MODELS, MONKEYS, MOVING TARGETS, NEUROLOGY, ORGANOPHOSPHATES, PARASYMPATHOMIMETIC AGENTS, POISONING, PREVENTIVE MEDICINE, SEARCHING, TARGETS, TEST AND EVALUATION, TOXICITY, TRACKING, VISION

Subject Categories : Pharmacology

Distribution Statement : APPROVED FOR PUBLIC RELEASE