Accession Number : ADA195558

Title :   Assessment of Neurological Effects of Drugs on Oculomotor and Visual Function in the Primate.

Descriptive Note : Final rept. 1 Sep 81-29 Feb 84; Annual rept. 1 Aug-29 Feb 84,

Corporate Author : STATE UNIV OF NEW YORK UPSTATE MEDICAL CENTER SYRACUSE

Personal Author(s) : Keating, E G

PDF Url : ADA195558

Report Date : 10 Oct 1984

Pagination or Media Count : 84

Abstract : Monkeys were given cholinergic drugs in doses considered to provide protection against organophosphate poisoning. Their eye movements were recorded while they carried out visual search and target tracking tasks. In general these agents had subtle effects. At the worst, monkeys remained capable of carrying out moderately good search and tracking performance. Pyridostigmine (7 mg/K) was the most benign, having no observable effect. Pralidoxime impaired behavior only at the highest dose (16 mg/K). Similarly, atropine and physostigmine degraded performance clearly and consistently only at the highest dose tested (.25 mg/K and .075 mg/K respectively). Degraded search and tracking was generally attributable to impaired oculomotor competence, rather than to altered visual, cognitive, or motivational status. Keywords: Antidotes. (AW)

Descriptors :   *ANTIDOTES, *EYE MOVEMENTS, *PARASYMPATHOMIMETIC AGENTS, *VISUAL PERCEPTION, ATROPINE, DOSAGE, DRUGS, MONKEYS, NEUROLOGY, ORGANOPHOSPHATES, PHYSOSTIGMINE, POISONING, SEARCHING, TARGETS, TRACKING, VISION, VISUAL PERCEPTION, ANTIDOTES, ATROPINE, DOSAGE, DRUGS, EYE MOVEMENTS, MONKEYS, NEUROLOGY, ORGANOPHOSPHATES, PARASYMPATHOMIMETIC AGENTS, PHYSOSTIGMINE, POISONING, SEARCHING, TARGETS, TRACKING, VISION

Subject Categories : Pharmacology

Distribution Statement : APPROVED FOR PUBLIC RELEASE