Accession Number : ADA195607

Title :   Prophylactic and Treatment Drugs for Organophosphorus Poisoning.

Descriptive Note : Annual rept. 30 Sep 85-29 Sep 86,

Corporate Author : ASH STEVENS INC DETROIT MI

Personal Author(s) : Stevens, C. L. ; Blumbergs, P. ; Knutson, P. L. ; Parks, C. L.

Report Date : JUL 1987

Pagination or Media Count : 53

Abstract : The program is directed at the design and synthesis of candidate treatment or prophylactic drugs as potential defense against organophosphorus poisoning. During the past year, 17 compounds were submitted: 7 organophosphates, 4 organophosphates, one carbamate, one pyridinealdoxime, one phosphinothioate, one phosphonothioate, one tropate ester and one tetraalkylammonium iodide. Keywords: Synthesis(chemistry); Chemotherapeutic agents; Antidotes. (KT).

Descriptors :   ALKYL RADICALS, AMMONIUM COMPOUNDS, ANTIDOTES, CARBAMATES, CHEMOTHERAPEUTIC AGENTS, DEFENSE SYSTEMS, DRUGS, IODIDES, ORGANIC PHOSPHORUS COMPOUNDS, POISONING, PREVENTIVE MEDICINE, SYNTHESIS, THERAPY.

Subject Categories : Pharmacology

Distribution Statement : APPROVED FOR PUBLIC RELEASE