Accession Number : ADA195704

Title :   Study of Erythrocyte Lipid Peroxidation and Deformability in Individuals with Sickle cell Trait (HBC).

Descriptive Note : Annual rept.,

Corporate Author : MEHARRY MEDICAL COLL NASHVILLE TN

Personal Author(s) : Das, Salil K

PDF Url : ADA195704

Report Date : 14 Feb 1988

Pagination or Media Count : 23

Abstract : Tread mill exercise causes an increase in the activity of SOD, GSHPx and 6-PGA dehydrogenase without any change in the activity of catalase and G-6-P dehydrogenase in SCT RBC. However, it did not affect the activity of any of the peroxide scavengers, but increased the activity of both NADPH generating enzymes in normal. Exercise did not have any significant effect on lipid peroxidation potential of either normal or SCT RBC. However, it caused an increase in the calcium content in SCT which was associated with an increase in the activity of sodium, potassium - calcium -ATPases of RBC membranes. Furthermore, exercise caused an increase in the amount of light membranes in SCT RBC. Keywords: Sickle cell trait; Physical stress; Lipid peroxidation; Deformability; Exercise(Physiology). (KT)

Descriptors :   *ERYTHROCYTES, *LIPIDS, *SICKLE CELLS, *PEROXIDES, CATALASE, ENZYMES, EXERCISE(PHYSIOLOGY), GRASSES, LIGHT, MEMBRANES, OXIDATION, POTASSIUM, SODIUM, STRESS(PHYSIOLOGY), TREADS

Subject Categories : Medicine and Medical Research

Distribution Statement : APPROVED FOR PUBLIC RELEASE