Accession Number : ADA195710

Title :   Biological Evaluation of Radioprotective Drugs.

Descriptive Note : Annual rept. 1 Feb 87-31 Jan 88,

Corporate Author : M D ANDERSON CANCER CENTER HOUSTON TX

Personal Author(s) : Murry, David

PDF Url : ADA195710

Report Date : 01 Mar 1988

Pagination or Media Count : 76

Abstract : The cellular and molecular mechanisms of radioprotection by aminothiols are being investigated through the use of both cultured mammalian (CHO) cells and a whole-animal model, specific-pathogen free mice. For each of these systems, detailed structure-activity relationships are being compiled which relate the effects of the different drugs on various endpoints for the survival of clonogenic cells and on the induction and repair of several types of DNA lesions in these same cells. The data obtained with cultured cells are used as a means of understanding or predicting the effects on tissues. A major finding is that tissue oxygenation appears to play an important role in determining both the extent and mechanism of protection, and that understanding the interrelationships between oxygen, aminothiols and radiation sensitivity will be a crucial step in our ability to utilize such drugs effectively. Keywords: Radioprotection; Aminothiols; Cultured cells; Jejunum; Bone marrow; Mouse; Cell survival; Animal survival; DNA Damage; Radioprotective agents. (KT)

Descriptors :   *RADIOPROTECTIVE AGENTS, *PHYSIOLOGICAL EFFECTS, AMINES, ANIMALS, BIOLOGY, BONE MARROW, CELLS(BIOLOGY), CYTOLOGY, DAMAGE, DEOXYRIBONUCLEIC ACIDS, JEJUNUM, LESIONS, MICE, NUCLEAR RADIATION PROTECTION, OXYGEN, RADIATION, SENSITIVITY, SURVIVABILITY, TEST AND EVALUATION, THIOLS, RADIATION TOLERANCE, MOLECULE MOLECULE INTERACTIONS

Subject Categories : Pharmacology

Distribution Statement : APPROVED FOR PUBLIC RELEASE