Accession Number : ADA195715

Title :   Mechanisms of Chemical Modulation and Toxicity of the Immune System.

Descriptive Note : Annual rept. 15 Apr 87-14 Apr 88,

Corporate Author : OHIO STATE UNIV RESEARCH FOUNDATION COLUMBUS

Personal Author(s) : Tarr, Melinda J ; Olsen, Richard G

PDF Url : ADA195715

Report Date : 15 May 1988

Pagination or Media Count : 32

Abstract : The results of experiments performed during this reporting period assess possible mechanisms involved in immunoregulation by 1,1-Dimethylhydrazine (UDMH). Treatment of mice with UDMH suppresses activity and production of interleukin-1 (L1) by partially blocking (IL1) receptor expression. Interleukin-2 (IL2) activity and production was also suppressed by UDMH, although the basal level of IL2 receptor was not affected. UDMH may partially reverse the immunosuppressive effects of Corynebacterium parvum in mice by interfacing with PGE2 production, but not hydrogen peroxide. Preliminary results show UDMH may affect murine splenic T-lymphocyte populations defined by helper/inducer (L3T4) and suppressor/cytotoxic (LYT-2) monoclonal antibodies. Antigen presenting B-cells and macrophage also show variable la antigen expression upon exposure to UDMH. These experiments are just getting underway, but early results show UDMH increases intracellular Ca (++) within a few seconds of its addition to murine splenocytes in the resting state (without mitogen). The interaction of UDMH of intracellular (Ca(++) levels could help define mechanisms of UDMH-induced immunomodulation. Keywords: Toxicity. (AW)

Descriptors :   *IMMUNITY, *IMMUNOSUPPRESSION, ANTIBODIES, ANTIGENS, CHEMICALS, CLONES, CORYNEBACTERIUM, HYDROGEN PEROXIDE, INDUCTANCE, MICE, MODULATION, PHAGOCYTES, PRODUCTION, RETICULOENDOTHELIAL SYSTEM, SENSE ORGANS, TOXICITY

Subject Categories : Toxicology
      Biochemistry

Distribution Statement : APPROVED FOR PUBLIC RELEASE