Accession Number : ADA195784

Title :   Development and Testing of Living Skin Equivalent.

Descriptive Note : Final rept. 1 Sep 82-15 Mar 84; Annual rept. 1 Aug 83-15 Mar 84,

Corporate Author : MASSACHUSETTS INST OF TECH CAMBRIDGE

Personal Author(s) : Bell, Eugene

PDF Url : ADA195784

Report Date : 01 May 1988

Pagination or Media Count : 12

Abstract : Histology of grafts on recipient rat for up to 24 months showed that the matrix basket-weave pattern established at one month became more pronounced at one year. No hypertrophic scarring was observed in any skin-equivalent graft made although grafts of epidermis alone on a collagen bed without cells did result in scarring. Hypertrophy of the epidermis lessened between one month and one year, and at two years no hypertrophy was observed. Keywords: Isografts, Collagens, Fibroblasts, Wounds, Skin grafts, Skin(Anatomy), Skin substitutes. (kt)

Descriptors :   COLLAGEN, EPIDERMIS, FIBROBLASTS, HISTOLOGY, LIFE(BIOLOGY), RATS, SKIN GRAFTS, SUBSTITUTES, SURGICAL TRANSPLANTATION

Subject Categories : Medicine and Medical Research

Distribution Statement : APPROVED FOR PUBLIC RELEASE