Accession Number : ADA195948

Title :   Intrinsic Cholinergic Mechanisms Regulating Cerebral Blood Flow as a Target for Organo Phosphate Action.

Descriptive Note : Annual rept. 30 Sep 85-29 Sep 86,

Corporate Author : CORNELL UNIV MEDICAL COLL NEW YORK

Personal Author(s) : Reis, Donald J ; Arneric, Stephen ; Iadecola, Costantino

PDF Url : ADA195948

Report Date : Oct 1986

Pagination or Media Count : 62

Abstract : In year 02 we have finished one objective of demonstrating that the release of ACh is within the target area, the cerebral cortex, by establishing that the effect is blocked by local administration of atropine, and that the quantity of ACh released is small. Moreover, we have, by chemical and immunocytochemical methods, established that the source of ACh is likely to be small cholinergic nerves adjacent to cerebral vessels and/or ACh synthesized in capillary endothelium. Keywords: Acetylcholine, Atropine sulfate, Cerebral cortex, Cerebral blood flow, Choline acetyltransferase, Cortical microvessels, Electron microscopy, Fastigial nucleus, GABA, HPLC, Immunocytochemistry, Neurotransmitter release, Vasodilation, Rats, Cholinergic nerves. (AW)

Descriptors :   *ACETYLCHOLINE, *ATROPINE, *BLOOD CIRCULATION, *CHOLINERGIC NERVES, CAPILLARIES(ANATOMY), CEREBRAL CORTEX, CEREBRUM, CHEMICALS, CHOLINE ACETYLTRANSFERASE, CYTOCHEMISTRY, ELECTRON MICROSCOPY, ENDOTHELIUM, IMMUNIZATION, IMMUNOLOGY, NERVE TRANSMISSION, RATS, RELEASE, SULFATES, VASODILATION

Subject Categories : Biochemistry
      Pharmacology
      Anatomy and Physiology

Distribution Statement : APPROVED FOR PUBLIC RELEASE