Accession Number : ADA201800

Title :   Mutagenic Potential of Hydroxylamine Hydrochloride in the Ames Salmonella/Mammalian Microsome Mutagenicity Test.

Descriptive Note : Rept. for 21 Nov 84-1 Aug 85,

Corporate Author : LETTERMAN ARMY INST OF RESEARCH PRESIDIO OF SAN FRANCISCO CA

Personal Author(s) : Sano, Steven K. ; Harbell, John W. ; Korte, Don W., Jr

Report Date : OCT 1988

Pagination or Media Count : 36

Abstract : The mutagenic potential of HYDROXYLAMINE HYDROCHLORIDE (WR 740) was assessed in the Ames Salmonella/Mammalian Microsome Mutagenicity Test. Tester strains TA97, TA98, TA100, TA102, TA1535, TA1537, and TA1538 were exposed to doses ranging from 0.2 mg/plate to 8.2 x 10 to the minus 4 power mg/plate. In this test, HYDROXYLAMINE HYDROCHLORIDE produced a relatively high reversion rate at 2.5 x 10 to the minus 3 power mg/plate and 8.2 x 10 to the minus 4 power mg/plate in tester strain TA97, compared with the control (spontaneous revertant) plates. However, the spontaneous reversion rate was substantially lower than normally reported for TA97. HYDROXYLAMINE HYDROCHLORIDE also produced a relatively high reversion rate at .2 mg/plate and .06 6 mg/plate in tester strain TA1535. No mutagenic responses were observed for strains TA98, TA100, TA102, TA1537, and TA1538. A confirmatory test was conducted with strains TA97 and Ta1535. Mutagenicity, Genetic toxicology, ames test, HYDROXYLAMINE HYDROCHLORIDE. (jes)

Descriptors :   *TOXICOLOGY, GENETICS, MAMMALS, MICROSOMES, MUTAGENS, SALMONELLA.

Subject Categories : Toxicology

Distribution Statement : APPROVED FOR PUBLIC RELEASE