Accession Number : ADA201837

Title :   Expression of Immunogenic Virus Proteins in Eukaryotic Vector Systems.

Descriptive Note : Final rept. 1 Aug 84-31 Dec 87,

Corporate Author : UNIFORMED SERVICES UNIV OF THE HEALTH SCIENCES BETHESDA MD

Personal Author(s) : Hay, John

Report Date : 01 MAR 1988

Pagination or Media Count : 31

Abstract : The overall aim of the study is to develop, in a eukaryotic expression system, a means of producing Hantaan Virus (HTV) proteins which are involved in the immune response to virus infection. In order to achieve this , it will be necessary to clone ths S and M genomic segments of the virus, sequence them and define encoded genes. The expression system we have chosen is vaccinia virus, which both produces large amounts of cloned product and can also be employed as a live vaccine construct. (mjm)

Descriptors :   *IMMUNOGENS, *PROTEINS, *VIRUSES, CELLS(BIOLOGY), CLONES, CODING, DISEASE VECTORS, GENES, IMMUNITY, LIVE VACCINES, RESPONSE(BIOLOGY), VACCINIA VIRUS, VIRUS DISEASES.

Subject Categories : Biochemistry

Distribution Statement : APPROVED FOR PUBLIC RELEASE