Accession Number : ADA204501

Title :   Molecular Control of Serotonin (5HT) Synthesis and Release.

Descriptive Note : Final rept. 1 Sep 85-31 Aug 88,

Corporate Author : MEDICAL COLL OF PENNSYLVANIA PHILADELPHIA

Personal Author(s) : Walker, Richard F. ; Aloyo, Vincent J.

Report Date : 28 NOV 1988

Pagination or Media Count : 18

Abstract : This research investigated the mechanisms controlling serotonin release via activation of alpha 1 adrenergic receptors. Since these receptors have been linked to phosphoinositide second messengers, norepinephrine signals for serotonin release can be differenced by separate receptors and second messengers from those for serotonin metabolism. In addition, NE-mediated serotonin release can be modulated by intrinsic peptide whose specific mRNA's have been identified in pineal tissue. Keywords: Neurochemistry, Nerve cells. (AW)

Descriptors :   *BIOCHEMISTRY, *NEUROCHEMISTRY, ACTIVATION, METABOLISM, MOLECULES, NERVE CELLS, RELEASE, SEROTONIN, SIGNALS, SYNTHESIS.

Subject Categories : Biochemistry

Distribution Statement : APPROVED FOR PUBLIC RELEASE