Accession Number : ADA204894

Title :   Heat Exhaustion in a Rat Model: Lithium as a Biochemical Probe.

Descriptive Note : Rept. for 15 Jan-15 Oct 88,

Corporate Author : BOSTON UNIV MA SCHOOL OF MEDICINE

Personal Author(s) : Zeisel, Steven H

PDF Url : ADA204894

Report Date : 08 Nov 1988

Pagination or Media Count : 18

Abstract : Experimental methods have been developed and validated which will permit us to: 1) measure leakage of tissue enzymes (ALT, CPK, Alkaline phosphatase, LDH) during heat exposure in rats; 2) measure lithium concentrations in plasma using atomic absorption spectrophotometry; 3) measure total body water, extracellular fluid space, and intravascular fluid space in rats; 4) passively heat restrained rats and record changes in rectal temperature. Our objectives for future work include: 1) learn methods for study of unrestrained rats which are passively heated; 2) learn methods for study of rats actively heated using treadmill; 3) treat rats with lithium and determine whether passive restrained, unrestricted restrained, or actively heated lithium-treated rats can be differentiated from controls in terms of heating rate, tissue enzyme leakage, or body water distribution. Keywords: Fatigue physiology, Heat stroke, Heat exhaustion, Heat stress physiology. (aw)

Descriptors :   *BIOCHEMISTRY, *HEAT STRESS(PHYSIOLOGY), *HEAT STROKE, *LITHIUM, ABSORPTION SPECTRA, ALKALINITY, ANATOMICAL MODELS, ATOMIC PROPERTIES, BODY FLUIDS, BODY TEMPERATURE, ENZYMES, EXPOSURE(PHYSIOLOGY), FATIGUE(PHYSIOLOGY), HEAT, HEATING, PHOSPHATASES, PROBES, RATES, RATS, RECTUM, RESTRAINT, SPECTROPHOTOMETRY, TISSUES(BIOLOGY), WATER, WATER DISTRIBUTION

Subject Categories : Stress Physiology
      Biochemistry

Distribution Statement : APPROVED FOR PUBLIC RELEASE