Accession Number : ADA206506

Title :   A Program for the Study of Skeletal Muscle Catabolism Following Physical Trauma.

Descriptive Note : Annual rept. 21 Feb 87-20 Feb 88,

Corporate Author : BRIGHAM AND WOMEN'S HOSPITAL BOSTON MA

Personal Author(s) : Wilmore, Douglas W.

Report Date : 15 MAR 1988

Pagination or Media Count : 9

Abstract : These two studies examine the role of prostaglandins as mediators of the catabolic response. In the first study, we examined the effects of a cyclooxgenase inhibition on the catabolic response to operative stress. In a second study we examined the effect of PG2 infusion on skeletal muscle proteolysis. Following laparotomy and retroperitoneal dissection, dogs increase skeletal muscle proteolysis and excrete increased urinary nitrogen. Pretreatment with a cyclooxygenase inhibitor (Ibuprofen) diminished this response in six paired animals when examining whole animal data. Amino acid flux data is presently being processed. In additional studies, PGE2 was infused in one hind limb and the flux of amino acids monitored in both lower extremities. Leg blood flow increased markedly in the limb receiving the PGE2; substrate flux is presently being analyzed. Keywords: Post traumatic proteolysis. (AW)

Descriptors :   *CATABOLISM, *PROSTAGLANDIN, *MUSCLES, *ANTIINFLAMMATORY AGENTS, *ENZYME INHIBITORS, *TRAUMA, AMINO ACIDS, BLOOD CIRCULATION, DISSECTION, DOGS, EXTREMITIES, FLUX(RATE), INHIBITION, NITROGEN, RESPONSE(BIOLOGY), SUBSTRATES, URINE, PROTEIN METABOLISM, OXIDOREDUCTASES.

Subject Categories : Pharmacology
      Medicine and Medical Research
      Biochemistry

Distribution Statement : APPROVED FOR PUBLIC RELEASE