Accession Number : ADA214393

Title :   Development of Biodegradable Implants for Use in Maxillofacial Surgery.

Descriptive Note : Annual rept. 1 Dec 85-30 Nov 86,

Corporate Author : SOUTHERN RESEARCH INST BIRMINGHAM AL

Personal Author(s) : Dunn, Richard L. ; Kelley, Benjamin S. ; Potter, Amelia G.

Report Date : 07 APR 1987

Pagination or Media Count : 32

Abstract : Maxillofacial injury requiring open or closed reduction is a frequent result of modern military conflicts. Traditional reduction methodologies involve the use of metallic plates, screws, and wires, along with their associated problems. Therefore, biodegradable fixation appliances, which should provide initial rigidity but then gradually weaken so that newly-forming bone is exercised, have been investigated. COmposite plates made from poly (DL-lactide) and reinforced with calcium metaphosphate (CMP) fibers are very strong, but they weaken rapidly when exposed to an aqueous environment because of a disruption of the interface between the reinforcing fibers and polymer matrix. Coating the plates with a hydrophobic, biodegradable film slows this weakening, but more protection is required. Smaller-diameter fibers and better fiber wetting by the matrix also result in more stable composites, but even nonbiodegradable polymers reinforced with CMP fibers rapidly lose strength in saline. Methods to protect the fiber/polymer interface from fluid attack, such as fiber coatings, alternative bioresorbable glasses, and improved composite fabrication techniques have been investigated. Keywords: Resorbable implants; Boneplate; Fracture fixation; Calcium metaphosphate. (AW)

Descriptors :   *MAXILLA, *SURGICAL IMPLANTATION, *COMPOSITE MATERIALS, *BONE FRACTURES, FABRICATION, METHODOLOGY, PLATES, BIODETERIORATION, POLYMERS, CALCIUM, PHOSPHATES, FIBER REINFORCEMENT, PROTECTIVE COATINGS, HYDROPHOBIC PROPERTIES, DIAMETERS, WETTING, STRENGTH(MECHANICS), LOSSES, SALINE SOLUTION, GLASS.

Subject Categories : Medicine and Medical Research
      Medical Facilities, Equipment and Supplies
      Laminates and Composite Materials

Distribution Statement : APPROVED FOR PUBLIC RELEASE