Accession Number : ADA221340

Title :   Potential Benefits and Hazards of Humoral Immune Reactions Against HTLV-III.

Descriptive Note : Annual rept. 30 Sep 87-29 Sep 88,

Corporate Author : KAROLINSKA INST STOCKHOLM (SWEDEN)

Personal Author(s) : Wigzell, Hans ; Gidlund, Magnus ; Nilsson, Kenneth

Report Date : 20 SEP 1989

Pagination or Media Count : 18

Abstract : The present project is aiming to define components within the humoral immune response against (human immunodeficiency virus) which may act in a beneficial or detrimental manner for the host. Identification of such components may subsequently allow for the applied use of positive components or the elimination of negative reactions. One major focus of the project is to analyze the impact of humoral immunity in relation to the early events of HIV infection, that is, in the steps where virus particles or virus-producing cells come in contact with uninfected cells. In these studies we have developed assays allowing quantitative studies of early HIV binding and infection in presence or absence of antibodies against HIV. Using fresh monocytes or human monocytoid cell lines and subclones from such cells it has been possible to show that antibodies against HIV may at high concentrations neutralize the virus, that is, block infection in vitro. Keywords: HIV, Immunity benefit hazard, RA 1, CD4, Gp120, Viral enhancement, Antiserum. (jg)

Descriptors :   *HUMORAL IMMUNITY, ANTIBODIES, CELLS, CONCENTRATION(COMPOSITION), ELIMINATION REACTIONS, HAZARDS, HUMAN IMMUNODEFICIENCY VIRUSES, IMMUNE SERUMS, IMMUNITY, IMPACT, IN VITRO ANALYSIS, INFECTIOUS DISEASES, MONOCYTES, OPTIMIZATION, PARTICLES, VIRUSES.

Subject Categories : Microbiology

Distribution Statement : APPROVED FOR PUBLIC RELEASE