Accession Number : ADA238007

Title :   Royal Society of Chemistry, Heterocyclic Chemistry Group, Lakeland Heterocyclic Symposium (10th), Held in Grasmere 9-13 May 1991.

Corporate Author : SUNDERLAND POLYTECHNIC (UNITED KINGDOM)

Report Date : MAY 1991

Pagination or Media Count : 39

Abstract : Analogues of the natural nucleosides continue to provide most of today's clinically useful anti-viral drugs. Their anti-viral properties generally result from inhibition of one or more of the key viral processing enzymes, or from incorporation into viral DNA or RNA, and subsequent chain termination of nucleic acid synthesis. The early analogues generally involved changes in the natural bases, and only following the success of acyclovir (1), and then zidovudine (2), was attention turned in earnest to analogues in which the sugar ring was modified. During the eighties, cyclopentanoid nucleosides, such as carbovir, attracted immense attention, but one variant of the nucleoside analogue type remained relatively unexplored - that of substitution of the sugar ring oxygen by sulphur, to give thiolanes. Although the corresponding 4-thiafuranose sugars have been reported in the literature, examples of their transformation into nucleoside analogues have been relatively rare. In part this has been due to the lack of robust, general routes to 4'-thianucleosides, and the subject of the presentation will be the development of just such a route.

Descriptors :   ANTIVIRAL AGENTS, BIOSYNTHESIS, CHAINS, CHEMISTRY, DEOXYRIBONUCLEIC ACIDS, DRUGS, ENZYMES, HETEROCYCLIC COMPOUNDS, INHIBITION, NUCLEIC ACIDS, NUCLEOSIDES, OXYGEN, PROCESSING, RINGS, SUGARS, SULFUR, SYMPOSIA, VIRUSES.

Subject Categories : Physical Chemistry

Distribution Statement : APPROVED FOR PUBLIC RELEASE