Accession Number : ADA247579

Title :   The Relationship between Vasoactive Intestinal Polypeptide and Whole-Body Sweat Rate during Exercise.

Descriptive Note : Interim rept. May-Dec 90,

Corporate Author : NAVAL HEALTH RESEARCH CENTER SAN DIEGO CA

Personal Author(s) : Buono, M. J. ; Dyar, D. ; Bulbulian, R. ; Sucec, A. A. ; Heaney, J.

Report Date : 28 DEC 1990

Pagination or Media Count : 10

Abstract : The purpose of this study was to examine the relationship between vasoactive intestinal polypeptide (VIP) and sweat rate during exercise. Seven male volunteers performed one hour of exercise at 60% of their maximal oxygen uptake (VO2 max) in 15 degC, 25 degC, and 35 degC conditions. Vasoactive intestinal polypeptide, whole-body sweat rate, and forearm skin blood flow were measured during each condition. Sweat rate and delta VIP (postexercise value minus preexercise value) demonstrated a significant (p < 0.05) linear relationship, with r = 0.73. Forearm skin blood flow and VIP were also linearly related, with r = 0.46 (p < 0.05). These results support the hypothesis that active cutaneous vasodilation and sweat rate are physiologically linked via the co-release of acetylcholine and VIP at the eccrine sweat gland. Furthermore, these findings strongly suggest that VIP plays a role in the human thermoregulatory response to exercise in the heat. Heat; exercise; sweat rate; vasoactive intestinal peptide (VIP); blood flow

Descriptors :   *SWEAT GLANDS, *VASODILATION, *PEPTIDES, ACETYLCHOLINE, BLOOD, BODIES, DELTAS, FLOW, GLANDS, HEAT, HUMANS, MALES, OXYGEN, RATES, RELEASE, RESPONSE, VALUE, VOLUNTEERS, EXERCISE(PHYSIOLOGY).

Subject Categories : Biology

Distribution Statement : APPROVED FOR PUBLIC RELEASE