Accession Number : ADA259275

Title :   Preclinical Toxicology Studies For New Drugs and Vaccines.

Descriptive Note : Annual rept. 15 Nov 91-14 Nov 92,

Corporate Author : ILLINOIS UNIV AT CHICAGO CIRCLE DEPT OF PHARMACOLOGY

Personal Author(s) : Levine, Barry S.

Report Date : 07 DEC 1992

Pagination or Media Count : 5

Abstract : The purpose of this study is to determine specific target organ toxicity, dose-response relationships, and a no adverse effect level of WR6026 in Beagle dogs following thirteen weeks of daily oral administration. In addition, the reversibility of these toxic effects over a 90-day recovery period will be assessed. Treatment was initiated on 5/7/92. Necropsies were conducted on 8/6-7/92 and 11/5-6/92 after the three month treatment period and a three month recovery period, respectively.

Descriptors :   *TOXICITY, *DRUGS, *VACCINES, *ORAL DOSAGE, TOXICOLOGY, TOXIC HAZARDS, ORGANS(ANATOMY), MUTAGENS.

Subject Categories : Toxicology
      Pharmacology

Distribution Statement : APPROVED FOR PUBLIC RELEASE