Accession Number : ADA267058

Title :   Novel Approaches to the Synthesis of Carfentanil

Descriptive Note : Final rept. May 1991-May 1992

Corporate Author : EDGEWOOD RESEARCH DEVELOPMENT AND ENGINEERING CENTER ABERDEEN PROVING GROUNDMD

Personal Author(s) : Fraser-Reid, Bertrand O. ; Taba, Kalula ; Banks, Harold D.

PDF Url : ADA267058

Report Date : MAY 1993

Pagination or Media Count : 22

Abstract : Three novel approaches to the synthesis of carfentanil were investigated that did not involve the hydrolysis of the corresponding a- aminonitrile. Starting with commercially available 1-benzyl-4-piperidone, regioselective cleavage of an a,B-exoxysulfone, an aza (3.3) sigmatropic rearrangement and aminolysis of a 1-bromo-1,2-diene were studied. Of these, the most promising was the sigmatropic rearrangement.... Carfentanil, Aza sigmatropic rearrangement, Piperidine.

Descriptors :   *SYNTHESIS(CHEMISTRY), *ANALGESICS, SYNTHESIS, STARTING, HYDROLYSIS, PHARMACOLOGY, CLEAVAGE, DIENES, APPROACH, MORPHINE, PIPERIDINES.

Subject Categories : Pharmacology

Distribution Statement : APPROVED FOR PUBLIC RELEASE