Accession Number : ADA269251

Title :   The Role of Chemical Inhibition of Gap Junctional Intercellular Communication in Toxicology.

Descriptive Note : Annual rept. 15 May 92-14 May 93,

Corporate Author : MICHIGAN STATE UNIV EAST LANSING DEPT OF PEDIATRICS/HUMAN DEVELOPMENT

Personal Author(s) : Trosko, James E. ; Madhukar, Burra V.

Report Date : 19 MAY 1993

Pagination or Media Count : 15

Abstract : Progress during this past grant period (3/1/92 - 4/30/93) has continued to mount, with new findings, new techniques to achieve our aims and objectives, and new support for our original working hypothesis that chemical modulation of gap junctional intercellular communication (GJIC) is involved in multiple formats of toxicity. We now have evidence on how certain tumor promoting chemicals, neurotoxicants, reproductive toxicants, teratogens or immunotoxicants can affect GJIC at either the transcriptional, translational or posttranslational levels. Using cells (a) mutated for altered GJIC; (b) transfected with various oncogenes; or (c) treated with different kinds of chemical toxicants, We have now elucidated the different mechanisms by which GJIC can be effected.. This new mechanistic understanding should contribute to a more biologically-based risk assessment model and an understanding of how epigenetic toxicants work. Gap junctions, Cell communication, Epigenetic toxicology, Neurotoxicants, Tumor promoters, Oncogenes, Chemical toxicity.

Descriptors :   *CHEMICALS, *TOXICOLOGY, *MOLECULAR BIOLOGY, *INHIBITION, CELLS(BIOLOGY), CHEMICAL REACTIONS, FORMATS, GRANTS, JUNCTIONS, MODELS, MODULATION, MOUNTS, NEOPLASMS, RISK, TOXICITY, WORK, IN VITRO ANALYSIS, BIOCHEMISTRY, ANTIBODIES, BIOLOGY, FUNCTIONS, DISEASES, GENES, REGULATIONS, TOOLS, PROTEINS, MUTAGENS, REPRODUCTIVE SYSTEM, IMAGES, TERATOGENIC COMPOUNDS.

Subject Categories : Biochemistry
      Toxicology

Distribution Statement : APPROVED FOR PUBLIC RELEASE