Accession Number : ADA271582

Title :   Non-Ionic Surfactants in the Treatment of Third Degree Burns.

Descriptive Note : Final rept. 1 Feb 90-31 Jul 93,

Corporate Author : DWIGHT DAVID EISENHOWER ARMY MEDICAL CENTER FORT GORDON GA

Personal Author(s) : McPherson, James C.

Report Date : 01 SEP 1993

Pagination or Media Count : 35

Abstract : Pluronic polyols are non-ionic surfactants developed in the 1950's. They are block co-polymers or the ABA type where A is made up of ethylene oxide polymers and B is propylene oxide polymers. They differ only in their molecular weight. The Pluronic polyols have been shown to be non-toxic. This protocol evaluates their effect on third degree scald burn in a rat model, pluronic polyols were administered 30 minutes following a third degree scald burn to the chest of 300-320 gram male rats. Histological evaluation documented this burn. The Pluronic polyol was administered intravenously at a concentration of 12mm/1 with a dose of 8ml/kg body weight. Animals were followed for four weeks (complete healing)

Descriptors :   *BURNS(INJURIES), *THERAPY, *SURFACE ACTIVE SUBSTANCES, WOUNDS AND INJURIES, IONIC CURRENT, ANIMALS, CLINICAL MEDICINE.

Subject Categories : Medicine and Medical Research
      Miscellaneous Materials

Distribution Statement : APPROVED FOR PUBLIC RELEASE