Accession Number : ADA272875

Title :   Annual Progress Report on Grant N00014-89-J-3073 (Massachusetts General Hospital).

Descriptive Note : Final rept.

Corporate Author : MASSACHUSETTS GENERAL HOSPITAL BOSTON

Personal Author(s) : Warren, H. S.

Report Date : 15 OCT 1993

Pagination or Media Count : 59

Abstract : Much has occurred since our last progress report and over the past year. As outlined in our initial grant, we have continued to focus on proteins and peptides that bind endotoxin and which are therefore candidates for the treatment of septic shock. Our grant was initially planned to terminate on June 30, 1992. In part because of a slow startup time and in part because of careful cost management, we had excess funds in the grant and requested an extension of the grant until June, 1993. Our work over the past year has been divided between three main subjects: (A) Analysis of monoclonal antibodies directed to lipid A; (B) Identification of the binding site of natural proteins that bind LPS through the use of overlapping synthetic peptides; and (C) Development of peptide-IgG conjugates based on the peptides in 'B' above.

Descriptors :   *ENDOTOXINS, *SYNTHESIS, *PEPTIDES, *LIPIDS, RECEPTOR SITES(PHYSIOLOGY), ANTIBODIES, METHODOLOGY, MONOCLONAL ANTIBODIES, IN VITRO ANALYSIS.

Subject Categories : Biochemistry
      Medicine and Medical Research

Distribution Statement : APPROVED FOR PUBLIC RELEASE