Accession Number : ADA276549

Title :   Preclinical Toxicology Studies of New Drugs and Vaccines.

Descriptive Note : Annual rept. 15 Nov 92-14 Nov 93,

Corporate Author : ILLINOIS UNIV AT CHICAGO CIRCLE

Personal Author(s) : Levine, Barry S.

Report Date : 13 DEC 1993

Pagination or Media Count : 12

Abstract : During the reporting period, Thirteen Week Oral Toxicity Studies of WR6026 with a Thirteen Week Recovery Period in dogs and rats, In Vitro Mutagenicity Tests of HI-6 Dichloride and an Acute Oral and intraperitoneal Toxicity Study of WR242511 and WR269410 in mice were completed and study reports were submitted. Draft reports were submitted for Thirteen Week Oral Toxicity Studies of WR238605 with a Thirteen Week Recovery Period in both dogs and rats. WR242511 and WR269410 were studied in a Chromosome Aberrations in Chinese Hamster Ovary (CHO) Cells Assay, a Salmonella/Mammalian-Microsome Plate Incorporation Mutagenicity Assay (Ames Test), a L5178Y TK +/- Mouse Lymphoma Mutagenesis Assay, and a Two Week Oral Dose Range-Finding Toxicity Study in rats. Draft reports were submitted for these studies. Lastly, an Acute Oral and Intraperitoneal Toxicity Study of WR242511 and WR269410 in rats was completed, and a draft report was submitted. Toxicity, Rats, Dogs, HI-6 Dichloride, WR242511, WR269410, WR6026, RA I, V, II.

Descriptors :   *TOXICITY, *VACCINES, *TOXICOLOGY, CELLS, CHROMOSOMES, DOGS, HAMSTERS, LYMPHOMAS, MICE, MICROSOMES, MUTATIONS, OVARIES, PLATES, RANGE FINDING, RATS, RECOVERY, SALMONELLA, TEST AND EVALUATION, DRUGS, IN VITRO ANALYSIS, MUTAGENS, ORAL DISEASES.

Subject Categories : Toxicology
      Medicine and Medical Research

Distribution Statement : APPROVED FOR PUBLIC RELEASE