Accession Number : ADA282599

Title :   Ultrashort Laser Pulse Effects in Ocular and Related Media: Laser-Induced Shock Wave Propagation and Retinal Damage.

Descriptive Note : Annual technical rept. 15 Apr 93-14 Apr 94,

Corporate Author : MASSACHUSETTS GENERAL HOSPITAL BOSTON WELLMAN LABS OF PHOTOMEDICINE

Personal Author(s) : Deutsch, T. F. ; Doukas, A. G. ; Flotte, T. ; Dorey, K. ; Lee, S.

Report Date : JUN 1994

Pagination or Media Count : 8

Abstract : The goals of this project are: (1) To develop assays for functional damage to retinal cells by pressure waves (stress transients); (2) To determine the acoustic properties of the aqueous and vitreous humors of the eye; and (3) To examine the effect of pressure waves to the retinal pigment epithelium in vitro. During this first year our efforts have been directed primarily at the first goal, with some initial efforts on the second. During this period we developed the capability of growing human retinal pigment epithelium (RPE) cells in culture, incorporating them intest capillaries, recovering them after exposure to stress transients and assessing cell damage

Descriptors :   *LASER MEDICAL DIAGNOSIS, *RETINA, ACOUSTIC PROPERTIES, ACOUSTICS, CELLS, CULTURE, DAMAGE, EPITHELIUM, EYE, HUMANS, PIGMENTS, PRESSURE, TRANSIENTS, SHOCK WAVES, DAMAGE ASSESSMENT.

Subject Categories : Medicine and Medical Research
      Anatomy and Physiology

Distribution Statement : APPROVED FOR PUBLIC RELEASE