Accession Number : ADA282637

Title :   Effects of Normobaric and Hyperbaric Oxygen on Survival, Regional Blood Flow and Tissue Oxygen Tension in Hemorrhagic Shock in Rats.

Descriptive Note : Final rept. 30 Sep 92-29 Sep 93,

Corporate Author : CARMEL HOSPITAL HAIFA (ISRAEL)

Personal Author(s) : Bitterman, Haim

Report Date : 30 NOV 1993

Pagination or Media Count : 23

Abstract : This study investigated mechanisms of the hemodynamic effects of oxygen in hemorrhagic shock induced by bleeding 35% of the total blood volume in rats. Hemorrhage induced a marked decrease in mean arterial blood pressure (MABP), a 40% decrease in blood flows to the hind quarters, the biceps femoris muscle, and the small bowel, as well as a 62% decrease in superior mesenteric artery (SMA) flow. This was accompanied by a 73% increase in resistance in the SMA vascular bed. Inhalation of 100% oxygen induced a significant increase of 33 + or -3 mmHg in MABP. This was accompanied by a significant increase in vascular resistance in the hind quarters and a concomitant decrease in blood flows in the distal aorta and the biceps femoris muscle. In contrast, oxygen did not change vascular resistance in the SMA bed, and induced a significant increase in blood flow to the SMA and small bowel. Administration of L-Arginine (100 mg/kg i.v) completely abolished the effects of oxygen on blood pressure and reversed its effects on blood flow and resistance in the hind quarters and biceps femoris muscle.

Descriptors :   *HEMORRHAGE, *HEMORRHAGIC SHOCK, *OXYGEN, AORTA, ARTERIES, BICEPS, BLOOD PRESSURE, BLOOD VOLUME, INHALATION, MUSCLES, RATS, RESISTANCE, BLOOD CIRCULATION, PATHOPHYSIOLOGY, THERAPY, HYPEROXIA.

Subject Categories : Medicine and Medical Research
      Anatomy and Physiology

Distribution Statement : APPROVED FOR PUBLIC RELEASE