Accession Number : ADA288907

Title :   Studies of Altered Response to Infection Induced by Severe Injury.

Descriptive Note : Midterm rept. 14 Apr 92-14 Oct 94,

Corporate Author : MASSACHUSETTS UNIV MEDICAL CENTER WORCESTER

Personal Author(s) : Miller-Graziano, Carol L.

PDF Url : ADA288907

Report Date : 15 NOV 1994

Pagination or Media Count : 46

Abstract : The Systemic Inflammatory Response Syndrome (SIRS) that frequently occurs post-injury'. is a major cause of post-trauma mortality and is characterized by both immunosuppression and cytokine aberrations. This research focuses on identifying the relative contributions of T cell and monocyte (M0) aberrations to SIRS. In the first half of the contract, we have shown that MO TNFa production (a major contributor to SIRS) is aberrantly increased in trauma patients by: 1 Failure to rapidly degrade TNFa mRNA leading to prolonged TNFa protein production: 2. Insensitivity to normal downregulation by prostaglandin E2 and TGFa; 3.Increased sensitivity' of MO to TNFa induction by LTB4; 4.Increased MO autocrine stimulation by TNFa due to stimulation through unshed TNFR: 5.Decreased production of the TNFa immunoregulatory cytokine IL-1O by patients MO and T lymphocytes: 6.Decreased T lymphocyte production of IF

Descriptors :   *WOUNDS AND INJURIES, *INFECTIOUS DISEASES, *BURNS(INJURIES), FUNCTIONS, STIMULATION(GENERAL), PRODUCTION, PROTEINS, SIGNS AND SYMPTOMS, IN VITRO ANALYSIS, PATIENTS, RESPONSE(BIOLOGY), T LYMPHOCYTES, HOSPITALS, MORTALITY RATE, INFLAMMATION, LYMPHOCYTES, INDUCTION SYSTEMS, IMMUNOSUPPRESSION, TRAUMA.

Subject Categories : Medicine and Medical Research
      Anatomy and Physiology

Distribution Statement : APPROVED FOR PUBLIC RELEASE