Accession Number : ADA290120

Title :   The Effects of Hydrazines on Neuronal Excitability.

Descriptive Note : Final rept. 30 Apr 92-31 Oct 93,

Corporate Author : VIRGINIA COMMONWEALTH UNIV RICHMOND

Personal Author(s) : DeLorenzo, Robert J.

PDF Url : ADA290120

Report Date : 31 OCT 1993

Pagination or Media Count : 18

Abstract : During the 4th of this research project, we have made considerable progress in directing our efforts at studying the effects of hydrazine on neuronal excitability and on individual ion currents. The initial studies have been exciting and have led to research that will provide the first documentation of the effects of this compound on isolated neurons. In addition, the ability to incorporate experiments into this project that will also allow us to investigate the effects of hydrazine on vertebrate neurons considerably expands the scope of our initial goals. Development of this technology in our laboratory over the last year will greatly enhance the application and feasibility of these studies. We have also been successful in characterizing specific ion currents and their sensitivity to specific anticonvulsant and convulsant drugs. These studies will allow us now to more rigorously investigate mechanisms that may block the toxic effects of hydrazine on the nervous system. %his last year has allowed us to expand our sample sizes and rigorously document our papers for publication. This study has accomplished its specific aims and demonstrated direct effects of hydrazines on the central nervous systems.

Descriptors :   *HYDRAZINES, *NERVE CELLS, *CENTRAL NERVOUS SYSTEM, *TOXICOLOGY, *MOTOR NEURONS, TOXICITY, ISOLATION, SENSITIVITY, VERTEBRATES, RESPIRATORY SYSTEM, NERVOUS SYSTEM, IONIC CURRENT, ANTICONVULSANTS.

Subject Categories : Psychology
      Toxicology
      Inorganic Chemistry

Distribution Statement : APPROVED FOR PUBLIC RELEASE