Accession Number : ADA290336

Title :   Malaria and Leishmaniasis Vector Ecology, Transmission, Immunology, Parasitology and Prophylaxis in Kenya.

Descriptive Note : Midterm rept.,

Corporate Author : KENYA MEDICAL RESEARCH INST NAIROBI

Personal Author(s) : Koech, Davy K.

PDF Url : ADA290336

Report Date : 19 APR 1994

Pagination or Media Count : 15

Abstract : Specific aims of the medical and biomedical research conducted in accordance with the statement of work for Cooperative Agreement DAHD17-92-V-2O12 have involved two tropical diseases of Kenya, malaria and leishmaniasis. Being major health risks, both diseases possess significant relevance to military operations in tropical and subtropical areas of the world. The growing capability to identify specific parasite proteins and through reverse methods identify, clone and express their DNA fragments, has increasingly directed attention of Walter Reed Army Institute of Research (WRAIR) scientists toward immunologic studies for malaria vaccine development. Additionally, special emphasis is focused on identity, characterization, and determining the role of cytokines that are significant in immunity to I malaria. In conjunction with these investigative efforts, arrangements are on-going to test two malaria vaccine candidates in Kenya. Studies of malaria vector ecology and transmission characterization is being accomplished to support the testing of the two and other malaria vaccine candidates. Production of serum-free medium for culture of cells and pathogenic protozoa have been developed and tested for production of parasite proteins free of exogeneous serum and other reactogenic molecules.

Descriptors :   *MALARIA, *MEDICAL RESEARCH, *LEISHMANIASIS, *PARASITOLOGY, *ECOLOGY, MILITARY OPERATIONS, RISK, PRODUCTION, MOLECULES, CELLS, HEALTH, PROTEINS, DISEASES, DEOXYRIBONUCLEIC ACIDS, REVERSIBLE, VECTOR ANALYSIS, TROPICAL REGIONS, IMMUNOLOGY, PARASITES, IMMUNITY, CULTURE, FRAGMENTS, PATHOGENIC MICROORGANISMS, BIOMEDICINE, VACCINES, PREVENTIVE MEDICINE, KENYA, PROTOZOA, SUBTROPICAL REGIONS, TROPICAL DISEASES.

Subject Categories : Microbiology
      Medicine and Medical Research

Distribution Statement : APPROVED FOR PUBLIC RELEASE