Accession Number : ADA290498

Title :   Coupling of Brain Muscarinic Receptors to Second Messengers.

Descriptive Note : Final rept. 1 Oct 91-30 Sep 94,

Corporate Author : MINNESOTA UNIV MINNEAPOLIS OFFICE OF RESEARCH AND TECHNOLOGY TRANSFER ADMINIS TRATION

Personal Author(s) : El-Fakahany, Esam E.

PDF Url : ADA290498

Report Date : 28 OCT 1994

Pagination or Media Count : 5

Abstract : Stimulating muscarinic acetylcholine receptors results in activation of various signal transduction pathways. The goal of the research was to investigate the selectivity of coupling of the currently known 5 subtypes of muscarinic receptors to these different second messenger pathways. Results indicate that m1, m3 and m5 muscarinic receptors are coupled to enhanced phosphoinositide hydrolysis, while m2 and m4 receptors are coupled to a decrease in cyclic AMP formation. Results also demonstrate efficient coupling of m5 muscarinic receptors to generation of nitric oxide.

Descriptors :   *COUPLING(INTERACTION), *ACETYLCHOLINE, *MUSCARINE, ACTIVATION, BRAIN, EFFICIENCY, SIGNALS, TRANSDUCERS, RECEPTION, NITROGEN OXIDES, NEUROTRANSMITTERS, CYCLIC COMPOUNDS, ADENOSINE PHOSPHATES, CHEMORECEPTORS.

Subject Categories : Biology
      Pharmacology

Distribution Statement : APPROVED FOR PUBLIC RELEASE