Accession Number : ADA290507

Title :   Electrical and Electronic Properties of Self-Assembled LIPID Bilayers.

Descriptive Note : Final rept. Apr 91-Jul 94,

Corporate Author : MICHIGAN STATE UNIV EAST LANSING DEPT OF PSYCHOLOGY

Personal Author(s) : Tien, H. T.

PDF Url : ADA290507

Report Date : 12 OCT 1994

Pagination or Media Count : 7

Abstract : Cell membranes play a pivotal role in signal transduction and information processing. This is owing to the fact that most physiological activities involve some kind of lipid bilayer-based receptor-ligand contact interactions. There are many outstanding examples such as ion sensing, antigen-antibody binding, and ligand-gated channels, to name a few. One approach to study these interactions in vitro is facilitated by employing artificial bilayer lipid membranes (BLMs). We have focused the efforts on ion and/or molecular selectivity and specificity using newly available self-assembled BLMs on solid support (i.e. s-BLMs), whose enhanced stability greatly aid in research areas of membrane biochemistry, biophysics and cell biology as well as in biosensor designs and molecular devices development. In this report, our current work along with the experiments done in collaboration with others on s-BLMs will be presented.

Descriptors :   *IONS, *MEMBRANES(BIOLOGY), *LAYERS, *LIPIDS, *ELECTRICAL PROPERTIES, *CELLS(BIOLOGY), DETECTION, INTERACTIONS, MOLECULES, BIOCHEMISTRY, IN VITRO ANALYSIS, SIGNALS, ANTIBODIES, TRANSDUCERS, PHYSIOLOGY, ANTIGENS, INFORMATION PROCESSING, BIOPHYSICS.

Subject Categories : Biology
      Biochemistry
      Electricity and Magnetism

Distribution Statement : APPROVED FOR PUBLIC RELEASE