Accession Number : ADA290682

Title :   Subchronic Toxicity Studies on l,3,5-Trinitrobenzene, 1,3-Dinitrobenzene, and Tetryl in Rats.

Descriptive Note : Final rept.,

Corporate Author : ENVIRONMENTAL PROTECTION AGENCY CINCINNATI OH ENVIRONMENTAL MONITORING AND SU PPORT LAB

Personal Author(s) : Reddy, Tirumuru V.

PDF Url : ADA290682

Report Date : 01 SEP 1994

Pagination or Media Count : 138

Abstract : Toxic effects of 1 ,3-Dinitrobenzene (1 ,3.DNB) in male and female F344 rats were evaluated by feeding powdered certified laboratory chow diet supplemented with varied concentrations of 1,3-DNB (0, 2.5, 10, 25, 75 and 150 mg/kg diet) for fourteen days. The average daily 1 ,3-DNB doses consumed were 0.21, 0.87, 2.02, 6.28 and 11.82 mg/kg b.w. for females and 0.21, 0.80, 1.98, 5.77 and 10.56 for males. Food consumption was significantly decreased in high dose animals of both sexes. Final body weights were not altered but relative organ weights were significantly changed in the 150 and 75 mg dose groups involving the spleen (males and females) and testes (males). Hematology and clinical chemistry studies indicated significantly increased values in both sexes relating to reticulocytes and methemoglobin in the 150 and 75 mg/kg dose groups while the red blood cell count, hemoglobin level and % hematocrit were decreased in these same groups. In addition, the levels of bilirubin, protein and albumin were increased in high dose males, Histopathological evaluations suggested that the susceptible organs for 1 ,3-DNB toxicity were kidneys (hyaline droplets), spleen (erythroid cell hyperplasia), brain (malacia and microgliosis), testes (seminiferous tubular degeneration). These changes were noted mainly in the 150 and 75 mg/kg dose groups except those changes involving the brain (150 mg/kg group only).

Descriptors :   *TOXICITY, *TETRYL, TEST AND EVALUATION, BRAIN, PROTEINS, COUNTING METHODS, CLINICAL MEDICINE, CHEMISTRY, WEIGHT, DOSAGE, TUBULAR STRUCTURES, ANIMALS, MALES, HEMOGLOBIN, ERYTHROCYTES, DIET, BODY WEIGHT, FEMALES, METHEMOGLOBIN, HISTOPATHOLOGY, SPLEEN, ORGANS(ANATOMY), FOOD CONSUMPTION, KIDNEYS, BILIRUBIN, BIODETERIORATION, HEMATOLOGY, TESTES.

Subject Categories : Toxicology
      Inorganic Chemistry

Distribution Statement : APPROVED FOR PUBLIC RELEASE