Accession Number : ADA291294

Title :   Cessation of Focal Epileptiform Activity Using Cortical Calcium Blocker.

Descriptive Note : Final rept. 8 Aug-31 Dec 94,

Corporate Author : UNIFORMED SERVICES UNIV OF THE HEALTH SCIENCES BETHESDA MD

Personal Author(s) : Bergman, William C. ; Moores, Leon E.

PDF Url : ADA291294

Report Date : 31 JAN 1995

Pagination or Media Count : 8

Abstract : 60-80 POUND MALE PIGS WERE SUBJECTED TO GENERAL ANESTHESIA, USING A BALANCED NARCOTIC TECHNIQUE (FENTANYL). The animals were then subjected to removal of the entire flat surface of the calvarium, as well as the dura (aside from the superior sagittal sinus). A cortical electroencephalographic (EEG) grid (PMT Corp.) was then placed over the surface of the exposed brain. Through a 3mm. hole in the grid, a seizure focus was established, using penicillin (5,000,000 U/cc.). Once this was definitively established, the penicillin was removed and replaced with a calcium channel blocker (nimodipine). In two out of four procedures, the focal epileptiform activity was ameliorated or altered.

Descriptors :   *CALCIUM, *PHARMACOLOGICAL ANTAGONISTS, EXPOSURE(GENERAL), BRAIN, GRIDS, ANIMALS, ANESTHESIA, PENICILLINS, ELECTROENCEPHALOGRAPHY, NARCOTICS, ANTICONVULSANTS, DURA MATER.

Subject Categories : Medicine and Medical Research
      Pharmacology

Distribution Statement : APPROVED FOR PUBLIC RELEASE