Accession Number : ADA291344

Title :   The Fibroblast Response to Anoxia: A Potential Direct Role in Wound Healing.

Descriptive Note : Final rept. 1 May 91-1 Nov 94,

Corporate Author : ROSWELL PARK CANCER INST BUFFALO NY

Personal Author(s) : Anderson, Garth R.

PDF Url : ADA291344

Report Date : 01 DEC 1994

Pagination or Media Count : 38

Abstract : Cellular anoxia constitutes an environmental stimulus experienced within early stage healing wounds. Anoxia has effects on fibroblasts which make important contributions to regulating the progressive events of wound healing. These effects are mediated through specific gene induction, resulting in activation of a cellular program including enhanced glycolysis, protease secretion, endonuclease production, and expression of an angiogenesis factor. In a delayed response, fibroblast contractile processes activate at a time appropriate for wound contraction. The anoxic fibroblast response is constitutively activated in a large fraction of malignancies, where it contributes to invasiveness and genomic instability.

Descriptors :   *WOUNDS AND INJURIES, *FIBROBLASTS, *HEALING, *ANOXIA, ACTIVATION, ENVIRONMENTS, CELLS, RESPONSE, GENES, STIMULI, MEDICAL SERVICES, INDUCTION SYSTEMS, CONTRACTION, SECRETION, PEPTIDE HYDROLASES, GLYCOLYSIS.

Subject Categories : Anatomy and Physiology
      Stress Physiology
      Medicine and Medical Research

Distribution Statement : APPROVED FOR PUBLIC RELEASE