Accession Number : ADA291997

Title :   The Influence of Hypoxia on the Pulmonary Microcirculation.

Descriptive Note : Final rept.,

Corporate Author : COLORADO UNIV AT DENVER MEDICAL CENTER

Personal Author(s) : Wagner, Wiltz W., Jr

PDF Url : ADA291997

Report Date : 01 MAR 1974

Pagination or Media Count : 8

Abstract : The objective of this research has been to study the effect of hypoxia on the pulmonary microcirculation. It has been well established that the pulmonary circulation has a vasopressor response to airway hypoxia. However, there is controversy over which vessels account for the increased resistance to blood flow. From the literature, it seems entirely possible that there is both a pulmonary arterial and a pulmonary venous component to this response. There is also evidence indicating that part of the response is intrinsic to the lung itself and another part is mediated by the sympathetic nervous system. A large part of the confusion stems from the inability of available techniques to resolve adequately the components of the pulmonary microcircu lation under in vivo conditions. For this reason, we developed a technique of implanting a transparent window in the chest wall of the dog to permit direct visualization of the pulmonary microcirculation. Considerable effort was devoted to the successful development of a system for arresting movement of the surface of the lung during spontaneous respiration. It was then possible to study the microcirculation using a surface illuminating microscope at magnifications up to oil immersion. It was also possible for us to control the animal's physiological condition such that his blood gases, blood pressures, and cardiac output were within normal limits during control conditions. pg 3. JMD

Descriptors :   *RESPIRATION, *BLOOD CIRCULATION, *PULMONARY VEINS, OUTPUT, CONTROL, RESISTANCE, LIMITATIONS, WALLS, LUNG, ARRESTING GEAR, HYPOXIA, THORAX, OILS, IN VIVO ANALYSIS, CIRCULATION, IMMERSION, HEART, DOGS, MAGNIFICATION, IMPLANTATION, SYMPATHETIC NERVOUS SYSTEM, BLOOD GASES.

Subject Categories : Anatomy and Physiology
      Medicine and Medical Research

Distribution Statement : APPROVED FOR PUBLIC RELEASE