Accession Number : ADA292489

Title :   Development of Novel Models for Describing Multiple Toxicity Effects.

Descriptive Note : Final rept. 20 Sep 91-31 Dec 94,

Corporate Author : DREXEL UNIV PHILADELPHIA PA ENVIRONMENTAL STUDIES INST

Personal Author(s) : Haas, Charles N. ; Frank, Maurice J.

PDF Url : ADA292489

Report Date : 24 FEB 1995

Pagination or Media Count : 95

Abstract : Models of additive and independent response of biological systems to mixtures of chemical agents have been modified to incorporate interactive (e.g., synergistic, or antagonistic) response. Computer programs to fit these models to experimental data have been developed. An extensive literature review was conducted to obtain data that could be used to test these models. A synoptic review of these data sets is presented. The models developed have, in general, provided an adequate degree of description of the behavior of the chemical mixtures in biological systems. The computer programs could be used for the analysis of data obtained in future experiments.

Descriptors :   *TOXICITY, COMPUTER PROGRAMS, DATA BASES, EXPERIMENTAL DATA, BIOLOGY, MODELS, LITERATURE SURVEYS, CHEMICALS, MIXTURES, RESPONSE, CHEMICAL AGENTS, ADDITIVES.

Subject Categories : Toxicology

Distribution Statement : APPROVED FOR PUBLIC RELEASE