Accession Number : ADA293742

Title :   Laser Induced Vitreoretinal Scarring - Evaluation of Causative Factors and a Therapeutic Approach.

Descriptive Note : Final rept. 1 Sep 91-30 Sep 94,

Corporate Author : TEL-AVIV UNIV (ISRAEL)

Personal Author(s) : Naveh, Nava ; Savion, Naphthali

PDF Url : ADA293742

Report Date : 10 MAR 1995

Pagination or Media Count : 50

Abstract : Eyes subjected to laser exposure develop an inflammatory reaction, lead to scattering, bleeding ensuing in visual impairment. This study demonstrated two main findings: (1) the angiogenic (neovascularization) activity of vitreous from lasered eye in rats cornea. The DPI an NADPH inhibitor curtailed significantly angiogenesis, as well as the initial vascular response. (2) vitreous of lasered eyes enhances cell proliferation of retinal pigment epithelium, vascular endothel. This unique finding explains the development of visual impairment weeks and months post laser of subjects unaware of being hit by laser. Therefore subjects exposed to laser should be screened regularly to find laser lesions and a therapeutic regimen of antioxidants and/or steroidal should be initiated.

Descriptors :   *WOUNDS AND INJURIES, *RETINA, *EYE, *LASER HAZARDS, *LASER DAMAGE, ISRAEL, SCATTERING, EPITHELIUM, EXPOSURE(GENERAL), RATS, LASERS, RESPONSE, THERAPY, EXPOSURE(PHYSIOLOGY), PIGMENTS, CELLS(BIOLOGY), INFLAMMATION, CARDIOVASCULAR SYSTEM, ANTIOXIDANTS, LESIONS, ANTIINFLAMMATORY AGENTS, VISUAL DEFECTS, HEMORRHAGE, CORNEA.

Subject Categories : Medicine and Medical Research
      Anatomy and Physiology
      Lasers and Masers

Distribution Statement : APPROVED FOR PUBLIC RELEASE